Information

Recombination of repeat elements generates somatic complexity in human genomes

Release:Jul 26, 2022 Update:Jan 11, 2023
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  • Press Release

Professor Yutaka Suzuki and Professor Martin Frith of the Department of Computational Biology and Medical Sciences in the Graduate School of Frontier Sciences played a leading role in the research project.

Highlights

  • Somatic recombination of Alu and L1 elements is widespread in the human genome
  • Somatic recombination events of Alu and L1 elements exhibit tissue-specific hallmarks
  • Neuronal differentiation of iPSCs is accompanied by changes in recombination profiles
  • Somatic recombination profiles are altered in Parkinson's and Alzheimer's diseases

Article

Publication: Cell
Title: Recombination of repeat elements generates somatic complexity in human genomes
Authors: Giovanni Pascarella, Chung Chau Hon, Kosuke Hashimoto, Annika Busch, Joachim Luginbühl, Callum Parr, Wing Hin Yip, Kazumi Abe, Anton Kratz, Alessandro Bonetti, Federico Agostini, Jessica Severin, Shigeo Murayama, Yutaka Suzuki, Stefano Gustincich, Martin Frith and Piero Carninci.
DOI: 10.1016/j.cell.2022.06.032

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