TSUCHIHARA Katsuya
(Visiting Professor/Division of Biosciences)
Department of Integrated Biosciences/Cancer Genomics, Translational Research
Career Summary
1993: Graduated from School of Medicine, Kanazawa University
2000: Received Ph.D. in Medicine from Tokyo Medical and Dental University
2000: Postdoctoral Fellow, Ontario Cancer Institute, University of Toronto
2005: Head, Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East
2013: Chief, Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center
2016: Chief, Division of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center
2018: Chief, Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center
Educational Activities
Graduate school:Breakthrough Now and Then, Seminar in Integrated Biosciences, Advanced Seminar in Integrated Biosciences, Research of Integrated Biosciences
Research Activities
It is necessary to obtain high-quality clinical information for cancer research. In addition, multi-omics data from patient specimens and model systems are indispensable to investigate the carcinogenic mechanism and the effects of therapeutic drugs. Several new multi-omics technologies such as single-cell analysis and microbiome analysis have been developed in recent years, and clinical sequence platforms enable us to obtain a large amount of omics-data with clinical information. Not only clinical and biological knowledge but also bioinformatics which extract meaningful information effectively is essential to integrate and analyze those data.
Literature
1. Suzuki A, Onodera K, Matsui K, Seki M, Esumi H, Soga T, Sugano S, Kohno T, Suzuki Y, Tsuchihara K. Characterization of cancer omics and drug perturbations in panels of lung cancer cells.Massive transcriptional start site analysis of human genes in hypoxia cells. Sci Rep. 2019;9:19529.
2. Mimaki S, Watanabe M, Kinoshita M, Yamashita R, Haeno H, Takemura S, Tanaka S, Marubashi S, Totsuka Y, Shibata T, Nakagama H, Ochiai A, Nakamori S, Kubo S, Tsuchihara K. Multifocal origin of occupational cholangiocarcinoma revealed by comparison of multilesion mutational profiles. Carcinogenesis. 2019 Jun 20. pii: bgz120. doi: 10.1093/carcin/bgz120. [Epub ahead of print]
3. Ikemura S, Yasuda H, Matsumoto S, Kamada M, Hamamoto J, Masuzawa K, Kobayashi K, Manabe T, Arai D, Nakachi I, Kawada I, Ishioka K, Nakamura M, Namkoong H, Naoki K, Ono F, Araki M, Kanada R, Ma B, Hayashi Y, Mimaki S, Yoh K, Kobayashi SS, Kohno T, Okuno Y, Goto K, Tsuchihara K, Soejima K. Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations. Proc Natl Acad Sci U S A. 2019 May 14;116(20):10025-10030.
Other Activities
Councilor, Japanese Cancer Association (JCA)
Member, Japanese Society of Medical Oncology (JSMO)
Member, The Molecular Biology Society of Japan (MBSJ)
Member, AmericanAssociation for Cancer Research (AACR)
Future Plan
Clarifying biological mechanisms dominating cancer cells and their microenvironment by comprehensive genome and epigenome analyses to achieve individualized precision medicine of cancer.
Messages to Students
Close collaboration between basic and clinical sciences is necessary to conquer cancer. Ambitious young researchers with diverse backgrounds are very welcome to our team.
URL
https://www.ncc.go.jp/en/epoc/division/translational_informatics/kashiwa/index.html