ISHII Genichiro
(Visiting Professor/Division of Biosciences)
Department of Integrated Biosciences/Generation of in vivo and in vitro models mimicking the cancer microenvironment, Biology of cancer associated fibroblasts (CAFs), Intrinsic and extrinsic factors affecting drug sensitivity .
Career Summary
1990: M.D, Kanazawa University School of Medicine.
1990: 1st Department of Pathology, Chiba University School of Medicine.
1994: Ph.D., Chiba University School of Medicine.
1994: Research associate, Chiba University School of Medicine.
2000: Lecturer, Chiba University School of Medicine.
2001: Section head, Pathology Division, National Cancer Center Research Institute East.
2005: Section head, Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East.
2012: Unit leader, Division of Pathology, Research Center for Innovative Oncology, National Cancer Center Hospital East.
Educational Activities
Other Universities: Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Life Science and Technology Track.
Research Activities
Generation of in vivo and in vitro models mimicking the cancer microenvironment (Refs.1-3,5,6).
Biology of cancer associated fibroblasts (CAFs) (Refs.1-4,6).
Intrinsic and extrinsic factors affecting therapeutic response (Ref.7;Review).
Literature
1) Ishii G., Sangai T., Oda T., Aoyagi Y., Hasebe T., Kanomata N., Endoh Y., Okumura C., Okuhara Y., Magae J., Emura M., Ochiya T.,and Ochiai A. Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction. Biochem Biophys Res. Commun. 309(1):232-40.2003.
2?) Ishii G., Sangai T., Sugiyama K., Ito T., Hasebe T., Endoh Y., Magae J.,and Ochiai A. In vivo immunophenotype of bone-marrow-derived fibroblasts recruited into fibrotic lesions. Stem cells. 23(5):699-706.2005.
3) Ishii G., Ito TK., Aoyagi K., Fujimoto H., Chiba H., Hasebe T., Fujii S., Nagai K., Sasaki H.,and Ochiai A. Presence of human circulating progenitor cells for cancer stromal fibroblasts in the blood of lung cancer patients. Stem cells. 25(6):1469-77.2007.
4) Ishii G., Hashimoto H., Asada K., Ito T., Hoshino A., Fujii S., Kojima M., Kuwata T., Harigaya K., Nagai K., Ushijima T.,and Ochiai A. Fibroblasts associated with cancer cells keep enhanced migration activity after separation from cancer cells;A novel character of tumor educated fibroblasts. Int.J.Oncol. 37(2):317-25.2010.
5) Ishii G., Atsumi N., Hoshino A.,and Ochiai A. Morphophenotype of floating colonies derived from a single cancer cell has a critical impact on tumor-forming activity. Pathol Int. 63(1):29-36.2013.
6) Neri S., Hashimoto H., Kii H., Watanabe H., Masutomi K., Kuwata T., Date H., Tsuboi M., Goto K., Ochiai A.,and Ishii G. Cancer cell invasion driven by extracellular matrix remodeling is dependent on the properties of cancer-associated fibroblasts. J Cancer Res Clin Oncol. [Epub ahead of print]2015.
7) Ishii G., Ochiai A.,and Neri S. Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment. Advanced Drug Delivery Review [Epub ahead of print]2015.
Other Activities
Japanese Cancer Association, Councilor.
The Japanese Society of Pathology, Councilor.
The Japan Lung Cancer Society, Councilor.
Editorial Board Member(Pathology International,The Scientific World JOURNAL, BioMed Research International, Journal of Stem Cells Research, Reviews & Reports), Associated Editor(Cancer Science).
Future Plan
We are trying to generate in vivo and in vitro models mimicking the cancer microenvironment by using fluorescence imaging and time-lapse imaging. We will resolve the phenotypic and functional heterogeneity of cancer cells and cancer-associated fibroblasts within the tumor microenvironment by analyzing single-cell dynamics. Our research goal is to reveal the novel biological mechansims of cancer progression and drug sensitvity based on the microenvironment context.
Research Activities and Prospect
Messages to Students
Seeing is believing.