Hiroshi Kiyono / Professor / Division of Biosciences
Department of Computational Biology and Medical Sciences / / Mucosal immunology, Mucosal vaccine, Allergy and inflammation

Career Summary
1979: D.D.S. (Nihon University, Matsudo)
1983: Ph.D. (University of Alabama, Birmingham)
1984-1987: Research and Clinical Assistant Professor (University of Alabama, Birmingham)
1986-1987: Visiting Senior Scientist (Max-Planck Institute for Biology)
1988-1990: Associate Professor (University of Alabama, Birmingham)
1991-2003: Professor (University of Alabama, Birmingham)
1992-1996: Co-Director (Immunobiology Vaccine Center, University of Alabama, Birmingham)
1994-2003: Professor and Chairman (Osaka University)
2004-present: Adjunct Professor (University of Alabama, Birmingham)
2003-present: Professor and Director (The University of Tokyo)
2005-2007: Chairman (Department of Microbiology and Immunology, The University of Tokyo)
2007-present: Adjunct Clinical Professor (Arizona State University)
2007-present: Associate Dean (The Institute of Medical Science, The University of Tokyo)
Educational Activities
Graduate school: Immunosurveillance system
Research Activities
Since the 1970s, I have been investigating and characterizing unique features of the mucosal immune system to establish mucosal immunology as an area of the immunology field as well as to develop effective and safe mucosal vaccines against infectious diseases and mucosal immune therapies against allergic and inflammatory diseases. We have recently developed cold-chain- and needle-free rice-based vaccines (MucoRice) with the cooperation of agricultural researchers. The vaccine antigens exogenously expressed in MucoRice are temperature-stable for at least 2.5 years and are resistant to digestive enzymes, thus they effectively induce vaccine antigen-specific protective immunity in both systemic and mucosal compartments against toxins produced by pathogenic microorganisms (e.g., cholera toxins). Additionally, our efforts aim to clarify the immunological cross-talk between the mucosal immune system and mucosal environmental factors (e.g., commensal bacteria and dietary materials) in immunological homeostasis. These studies will lead to the development of novel immune therapies against mucosal immune diseases, such as food allergy, rhinitis, and inflammatory bowel diseases.
1) Fujihashi, K. et al., Trends Immunol. (2009, in press)
2) Takahashi, I. et al., Curr. Opin. Immunol. (2009, in press)
3) Kunisawa, J. et al., Trends Immunol. (2008)
4) Kunisawa, J. et al., Blood (2008)
5) Nochi, T. et al., J. Exp. Med. (2007)
6) Fukuyama, S. et al., Immunity (2007)
7) Kunisawa, J. et al., J. Exp. Med. (2007)
8) McGhee, J. R. et al., Trends Immunol. (2007)
9) Kunisawa, J. et al., Immunol. Rev. (2007)
10) Nochi, T. et al., PNAS (2007)
11) Kunisawa, J. et al., Blood (2007)
12) Takagi, H. et al., PNAS (2005)
13) Kai, Y. et al., Gastroenterology (2005)
14) Jang, M. H. et al., PNAS (2004)
15) Kiyono, H. et al., Nat. Rev. Immunol. (2004)
16) Fukuyama, S. et al., Immunity (2002)
17) Kweon, M. N. et al., J. Clin. Invest. (2002)
18) Fujihashi, K. et al., PNAS (2001)
19) Kweon, M. N. et al., J. Clin. Invest. (2000)
Other Activities
1) Member of ADA National Board Test Construction Committee (1988-1993)
2) Member of NIH NIDR Study Section (1992-1997)
3) Evaluation Committee Member of Oral Biology Graduate Program, University of Oslo (1999-2000)
4) Board Member, Society for Mucosal Immunology (2003-present)
5) Board Member, The Japanese Society for Vaccinology (2003-present)
6) Board Member, The Japanese Society for Immunology (2005-present)
7) President, Society for Mucosal Immunology (2005-2007)
1) New Investigator Award, NIH, USA (1984)
2) Research Career Development Award, NIH, USA (1988)
3) Hideyo Noguchi Memorial Award (2007)
4) Takahashi Prize, The Japanese Society for Vaccinology (2007)
Future Plan
Our goal is to continuously advance our molecular and cellular understanding of the mucosal immune system to create novel mucosal vaccines and immunotherapies for the prevention and control of infectious and immunological diseases.
Messages to Students
We welcome all of you who are interested in the fascinating scientific world of mucosal immunology.