News

Computational Biology and Medical Sciences

Title
Date
A cross-population atlas of genetic associations for 220 human phenotypes 2021:10:06:14:46:51
Abstract Current genome-wide association studies do not yet capture sufficient diversity in populations and scope of phenotypes. To expand a...
 
2021/10/06
A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells 2021:08:27:10:50:47
Summary Paraspeckles are membraneless organelles formed through liquid-liquid phase separation and consist of multiple proteins and RNAs, in...
 
2021/08/27
Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma 2021:08:19:14:00:00
Abstract Subclonal genetic heterogeneity and their diverse gene expression impose serious problems in understanding the behavior of cancers...
 
2021/08/19
Mathematical modeling and mutational analysis reveal optimal therapy to prevent malignant transformation in grade II IDH-mutant gliomas 2021:08:03:14:09:56
Abstract WHO grade II isocitrate dehydrogenase mutant gliomas (IDHmut-LGGs) grow slowly but frequently undergo malignant transformation, wh...
 
2021/08/03
Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection 2021:06:17:18:41:29
Abstract Age is the dominant risk factor for infectious diseases, but the mechanisms linking age to infectious disease risk are incompletel...
 
2021/06/17
Eight novel susceptibility loci and putative causal variants in atopic dermatitis 2021:06:09:14:44:31
Background Atopic dermatitis (AD) is the most common allergic disease in the world. While genetic components play critical roles in its pat...
 
2021/06/09
Long-read whole-genome methylation patterning using enzymatic base conversion and nanopore sequencing 2021:05:25:10:58:44
Abstract Long-read whole-genome sequencing analysis of DNA methylation would provide useful information on the chromosomal context of gene e...
 
2021/05/25
A deep learning method for HLA imputation and trans-ethnic MHC fine-mapping of type 1 diabetes 2021:03:12:08:03:23
Abstract Conventional human leukocyte antigen (HLA) imputation methods drop their performance for infrequent alleles, which is one of the f...
 
2021/03/12
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries 2021:02:25:15:27:47
Abstract Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify risk loci, we conduct a large...
 
2021/02/25
Genome-wide SNP data of Izumo and Makurazaki populations support inner-dual structure model for origin of Yamato people 2021:02:19:11:30:02
Abstract The "Dual Structure" model on the formation of the modern Japanese population assumes that the indigenous hunter-gathering populat...
 
2021/02/19
Aberrant splicing isoforms detected by full-length transcriptome sequencing as transcripts of potential neoantigens in non-small cell lung cancer 2021:01:07:15:03:15
Abstract Background Long-read sequencing of full-length cDNAs enables the detection of structures of aberrant splicing isoforms in cancer...
 
2021/01/07
Chromosomal alterations among age-related haematopoietic clones in Japan 2020:06:25:12:00:00
Abstract The extent to which the biology of oncogenesis and ageing are shaped by factors that distinguish human populations is unknown. Hae...
 
2020/06/25
Large-scale genome-wide association study across different diseases in a Japanese population 2020:06:09:12:00:00
Abstract The overwhelming majority of participants in current genetic studies are of European ancestry. To elucidate disease biology in the...
 
2020/06/09
Prevalence of pathogenic germline variants with early-onset colorectal, breast, and prostate cancer 2020:04:09:12:00:00
Abstract PUPOSE We investigated the prevalence and spectrum of pathogenic germline variants in patients with early-onset colorectal cancer...
 
2020/04/09
Trans-biobank analysis elucidates the association of polygenic risk scores with human lifespan. 2020:03:24:12:00:00
Abstract While polygenic risk scores (PRSs) are poised to be translated into clinical practice through prediction of inborn health risks, a...
 
2020/03/24
2020/02/27
Essential role of the Crk family-dosage in DiGeorge-like anomaly and metabolic homeostasis 2020:02:12:12:00:00
Abstract CRK and CRKL (CRK-like) encode adapter proteins with similar biochemical properties. Here, we show that a 50% reduc...
 
2020/02/12
Phase separation organizes the site of autophagosome formation 2020:02:06:12:00:00
Abstract Many biomolecules undergo liquid–liquid phase separation to form liquid-like condensates that mediate diverse cellular functions. ...
 
2020/02/06
GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits 2020:02:03:12:00:00
Abstract Dietary habits are important factors in our lifestyle, and confer both susceptibility to and protection from a variety of human di...
 
2020/02/03
Liquidity is a critical determinant for selective autophagy of protein condensates 2020:01:29:12:00:00
Summary Clearance of biomolecular condensates by selective autophagy is thought to play a crucial role in cellular homeostasis. However, th...
 
2020/01/29
Targeting Excessive EZH1 and EZH2 Activities for the Epigenetic Abnormality of Malignant Lymphomas 2019:11:20:12:00:00
Highlights ・Lymphoma transcriptome is under control of global H3K27me3 accumulation ・EZH1 and EZH2 are druggable targets in EZH2WT/WT and ...
 
2019/11/20
GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation 2019:10:18:12:00:00
Abstract Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing men. However, the genetic architecture and b...
 
2019/10/18
Characterizing rare and low-frequency height-associated variants in the Japanese population 2019:10:02:12:00:00
Abstract Human height is a representative phenotype to elucidate genetic architecture. However, the majority of large studies have been per...
 
2019/10/02
New susceptibility loci for prostate cancer identified by genome-wide association study 2019:09:30:12:00:00
Genome-wide association studies (GWAS) have identified ~170 genetic loci associated with prostate cancer (PCa) risk, but most of them were i...
 
2019/09/30
Numerical operations in living cells by programmable RNA devices 2019:08:22:12:00:00
          細胞内の複数のマイクロRNAを同時に検知して 細胞を生きたまま精密に分けることに成功     ポイント メッセンジャーRNA(mRNA)注1)を細胞内に導入することで...
 
2019/08/22
2019/02/07
2018/12/06
2018/12/05
Autonomous gene expression control nanodevice will contribute to medical care 2018:08:20:12:00:00
Osaka University-led Japanese scientists construct integrated gene logic-chips called “gene nanochips” Gene expression is a fundamental of ...
 
2018/08/20
Dean's Award for Outstanding Achievement, Graduate School of Frontier Sciences 2018 2018:04:13:12:00:00
The recipients of the Dean's Award for Outstanding Achievement (Master course 12 students, Doctoral course 11 students) GSFS 2018 were annou...
 
2018/04/13
Dean's Award for Outstanding Achievement, Graduate School of Frontier Sciences 2017 2017:03:30:12:00:00
The recipients of the Dean's Award for Outstanding Achievement (Master course 12 students, Doctoral course 12 students)  GSFS 2017 were...
 
2017/03/30
Commencement of First-in-Human Clinical Trial for New Molecular Targeting Drug 2016:04:07:12:00:00
  National Cancer Center The University of Tokyo Daiichi Sankyo Company, Limited    Commencement of First-in-Human Clini...
 
2016/04/07
2015/08/17
2015/08/17
Visualizing RNAi at work 2015:07:03:12:00:00
How does single "RISC" accurately cleave and release target RNAs? University of Tokyo and Kyoto University researchers have revealed the mo...
 
2015/07/03

1