Computational Biology and Medical Sciences

A cross-population atlas of genetic associations for 220 human phenotypes 2021:10:06:14:46:51
Abstract Current genome-wide association studies do not yet capture sufficient diversity in populations and scope of phenotypes. To expand a...
A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells 2021:08:27:10:50:47
Summary Paraspeckles are membraneless organelles formed through liquid-liquid phase separation and consist of multiple proteins and RNAs, in...
Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma 2021:08:19:14:00:00
Abstract Subclonal genetic heterogeneity and their diverse gene expression impose serious problems in understanding the behavior of cancers...
Mathematical modeling and mutational analysis reveal optimal therapy to prevent malignant transformation in grade II IDH-mutant gliomas 2021:08:03:14:09:56
Abstract WHO grade II isocitrate dehydrogenase mutant gliomas (IDHmut-LGGs) grow slowly but frequently undergo malignant transformation, wh...
Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection 2021:06:17:18:41:29
Abstract Age is the dominant risk factor for infectious diseases, but the mechanisms linking age to infectious disease risk are incompletel...
Eight novel susceptibility loci and putative causal variants in atopic dermatitis 2021:06:09:14:44:31
Background Atopic dermatitis (AD) is the most common allergic disease in the world. While genetic components play critical roles in its pat...
Long-read whole-genome methylation patterning using enzymatic base conversion and nanopore sequencing 2021:05:25:10:58:44
Abstract Long-read whole-genome sequencing analysis of DNA methylation would provide useful information on the chromosomal context of gene e...
A deep learning method for HLA imputation and trans-ethnic MHC fine-mapping of type 1 diabetes 2021:03:12:08:03:23
Abstract Conventional human leukocyte antigen (HLA) imputation methods drop their performance for infrequent alleles, which is one of the f...
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries 2021:02:25:15:27:47
Abstract Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify risk loci, we conduct a large...
Genome-wide SNP data of Izumo and Makurazaki populations support inner-dual structure model for origin of Yamato people 2021:02:19:11:30:02
Abstract The "Dual Structure" model on the formation of the modern Japanese population assumes that the indigenous hunter-gathering populat...
Aberrant splicing isoforms detected by full-length transcriptome sequencing as transcripts of potential neoantigens in non-small cell lung cancer 2021:01:07:15:03:15
Abstract Background Long-read sequencing of full-length cDNAs enables the detection of structures of aberrant splicing isoforms in cancer...
Chromosomal alterations among age-related haematopoietic clones in Japan 2020:06:25:12:00:00
Abstract The extent to which the biology of oncogenesis and ageing are shaped by factors that distinguish human populations is unknown. Hae...
Large-scale genome-wide association study across different diseases in a Japanese population 2020:06:09:12:00:00
Abstract The overwhelming majority of participants in current genetic studies are of European ancestry. To elucidate disease biology in the...
Prevalence of pathogenic germline variants with early-onset colorectal, breast, and prostate cancer 2020:04:09:12:00:00
Abstract PUPOSE We investigated the prevalence and spectrum of pathogenic germline variants in patients with early-onset colorectal cancer...
Trans-biobank analysis elucidates the association of polygenic risk scores with human lifespan. 2020:03:24:12:00:00
Abstract While polygenic risk scores (PRSs) are poised to be translated into clinical practice through prediction of inborn health risks, a...
Essential role of the Crk family-dosage in DiGeorge-like anomaly and metabolic homeostasis 2020:02:12:12:00:00
Abstract CRK and CRKL (CRK-like) encode adapter proteins with similar biochemical properties. Here, we show that a 50% reduc...
Phase separation organizes the site of autophagosome formation 2020:02:06:12:00:00
Abstract Many biomolecules undergo liquid–liquid phase separation to form liquid-like condensates that mediate diverse cellular functions. ...
GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits 2020:02:03:12:00:00
Abstract Dietary habits are important factors in our lifestyle, and confer both susceptibility to and protection from a variety of human di...
Liquidity is a critical determinant for selective autophagy of protein condensates 2020:01:29:12:00:00
Summary Clearance of biomolecular condensates by selective autophagy is thought to play a crucial role in cellular homeostasis. However, th...
Targeting Excessive EZH1 and EZH2 Activities for the Epigenetic Abnormality of Malignant Lymphomas 2019:11:20:12:00:00
Highlights ・Lymphoma transcriptome is under control of global H3K27me3 accumulation ・EZH1 and EZH2 are druggable targets in EZH2WT/WT and ...
GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation 2019:10:18:12:00:00
Abstract Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing men. However, the genetic architecture and b...
Characterizing rare and low-frequency height-associated variants in the Japanese population 2019:10:02:12:00:00
Abstract Human height is a representative phenotype to elucidate genetic architecture. However, the majority of large studies have been per...
New susceptibility loci for prostate cancer identified by genome-wide association study 2019:09:30:12:00:00
Genome-wide association studies (GWAS) have identified ~170 genetic loci associated with prostate cancer (PCa) risk, but most of them were i...
Numerical operations in living cells by programmable RNA devices 2019:08:22:12:00:00
          細胞内の複数のマイクロRNAを同時に検知して 細胞を生きたまま精密に分けることに成功     ポイント メッセンジャーRNA(mRNA)注1)を細胞内に導入することで...
Autonomous gene expression control nanodevice will contribute to medical care 2018:08:20:12:00:00
Osaka University-led Japanese scientists construct integrated gene logic-chips called “gene nanochips” Gene expression is a fundamental of ...
Dean's Award for Outstanding Achievement, Graduate School of Frontier Sciences 2018 2018:04:13:12:00:00
The recipients of the Dean's Award for Outstanding Achievement (Master course 12 students, Doctoral course 11 students) GSFS 2018 were annou...
Dean's Award for Outstanding Achievement, Graduate School of Frontier Sciences 2017 2017:03:30:12:00:00
The recipients of the Dean's Award for Outstanding Achievement (Master course 12 students, Doctoral course 12 students)  GSFS 2017 were...
Commencement of First-in-Human Clinical Trial for New Molecular Targeting Drug 2016:04:07:12:00:00
  National Cancer Center The University of Tokyo Daiichi Sankyo Company, Limited    Commencement of First-in-Human Clini...
Visualizing RNAi at work 2015:07:03:12:00:00
How does single "RISC" accurately cleave and release target RNAs? University of Tokyo and Kyoto University researchers have revealed the mo...