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Yusei Miyamoto / Professor / Division of Biosciences
Department of Integrated Biosciences / Biochemistry of Cell Resposiveness / Application of nanotechnology to biosciences

Career Summary
1982: Quitted, Grad School of Pharmaceutical Sci, Univ of Tokyo
1982: Faculty, Univ of Tokyo
1984: Doctor of Pharmaceutical Sci from Univ of Tokyo
1984: Research Associate, Univ of Tokyo
1985: Postdoctoral Fellow, Medical College of Georgia
1989: Assistant Prof, Medical College of Georgia
1994: Visiting Assistant Prof, UC Berkley
1997: Associate Prof, Univ of Tokyo
1999: Prof, Univ of Tokyo
Educational Activities
Graduate School: Biochemistry of cell responsiveness, English writing course for publication, English practice for presentation

Undergraduate School: Research practice
Research Activities
Recently, we found antioxidant activity of noble metal nanoparticles. They seem to scavenge reactive oxygen species and free radicals in catalytic manners. Currently, we are testing their effects on aging and oxidative stress diseases using animal disease models and cell lines. We are also interested in the precise mechanisms of their scavenging reaction.
Literature
1) Masashi Kajita, Keisuke Hikosaka, Mayumi Iitsuka, Atsuhiro Kanayama, Naoki Toshima, and Yusei Miyamoto. Platinum nanoparticle is a useful scavenger of superoxide anion and hydrogen peroxide. Free Radical Research 41(6): 615-626, 2007.
2) Masashi Kajita, Keisuke Hikosaka, Mayumi Iitsuka, Atsuhiro Kanayama, Naoki Toshima, and Yusei Miyamoto. SOD/catalase mimetic activity of platinum nanoparticles. Program and Abstract for 12th IUPAC International Symposium on MacroMolecular Complexe, p227, 2007.
3) Atsuhiro Kanayama and Yusei Miyamoto. Apoptosis triggered by phagocytosis related oxidative stress through FLIPs down-regulation and JNK activation. J Leukocyte Biol 82(11), 2007 (in press).
Other Activities
Japan Society for Bioscience, Biotechnology and Agrochemistry
Chemical Society of Japan
Division of Colloid and Interface Chemistry
Japanese Society of Immunology
Vice chairman of NPO Biotech Consortium
Technical adviser of Apt Co LTD
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Future Plan
We plant to establish procedures to apply noble metal nanoparticles to medical treatment of oxidative stress diseases and to further develop new biological uses.
Messages to Students
I hope that our active participation in science leads to the betterment of society.
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