Yoichi Furukawa / Professor / Division of Biosciences
Department of Computational Biology and Medical Sciences / / Cancer genomics, Molecular genetics

Career Summary
1987: Graduated/M.D. (Faculty of Medicine, The University of Tokyo)
1987-1992: Medical doctor (Department of Surgery, The Tokyo Univ. Hospital)
1992-1996: Research Fellow (Department of Biochemistry, Cancer Institute, Tokyo)
1996-1997: Research Fellow (International Agency for Research on Cancer, WHO)
1996-1997: Assistant Professor (Department of Molecular Surgery, The Tokyo Univ. Hospital)
1999-2001: Assistant Professor (Laboratory of Molecular Medicine, IMSUT)
2001-2004: Associate Professor (Laboratory of Molecular Medicine, IMSUT)
2004-2007: Project Professor (21st COE program, IMSUT)
2007-present: Professor (Division of Clinical Genome Research, IMSUT)
Educational Activities
Graduate school: Molecular Pathology; Cancer Genome
Institute hospital: Genome Medicine, Genetic Counseling
Research Activities
1. Identification of tumor suppressor AXIN1 in hepatocarcinogenesis (1999-2001).
2. Global gene expression analysis of human colorectal, gastric, and liver carcinomas (2000-2004).
3. Analysis of histone methyltransferase associated with carcinogenesis (2004-ongoing)
1) Satoh, S., Daigo, Y., Furukawa, Y., Kato, T., Miwa, N., Nishiwaki, T., Kawasoe, T., Ishiguro, H., Fujita, M., Tokino, T., Sasaki, Y., Imaoka, S., Murata, M., Shimano, T., Yamaoka, Y., & Nakamura, Y. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nature Genet. 24(3): 245-250, 2000.

2) Okabe, H., Satoh, S., Kato, T., Kitahara, O., Yanagawa, R., Yamaoka, Y., Tsunoda, T., Furukawa, Y., & Nakamura, Y. Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray; Identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res. 61(5): 2129-2137, 2001.

3) Lin, Y.-M., Furukawa, Y., Tsunoda, T., Yue, C.-T., Yang, K.-C., & Nakamura, Y. Molecular diagnosis of colorectal tumors by expression profiles of 50 genes expressed differentially in adenomas and carcinomas. Oncogene 21: 4120-4128, 2002.

4) Hasegawa, S., Furukawa, Y., Li, M., Satoh, S., Kato, T., Watanabe, T., Katagiri, T., Tsunoda, T., Yamaoka, Y., & Nakamura, Y. Genome-wide analysis of gene expression in intestinal-type gastric cancers using a complementary DNA microarray representing 23,040 genes. Cancer Res. 62: 7012-7017, 2002.

5) Hamamoto, R., Furukawa, Y., Morita, M., Iimura, Y., Silva, F. P., Li, M., Yagyu, R., & Nakamura, Y. SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nature Cell Biol. 6(8): 731-740, 2004.
Other Activities
American Association of Cancer Research (AACR)
Japanese Cancer Association (JCA)
The Japan Society of Human Genetics (JSHG)
Japan Surgical Society (JSS)
The Japan Society of Coloproctology (JSCP)
Future Plan
We are working on the basic research for clarifying the mechanisms of human cancer to apply our findings in clinics. In addition, I would like to nurture creative and motivated young scientists who will open a new avenue for medical genetics and bring our challenging spirit to the next generation.
Messages to Students
Young men and women, you have only one life but you have plenty of possibilities. If you try hard for your dream, you should attain something valuable, but if you waste your time, you will have nothing. Life is like a walk. Everybody can leave footprints. Scientists have a chance to leave lasting footprints, as their scientific work will be remembered for hundreds of years. Moreover, they can receive exciting findings as a reward for their daily work. So, please join us. You will take pleasure in your life and leave honorable achievements that will be appreciated not only by this generation but also by future ones.