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Tsunehiro TAKEDA / Professor / Division of Transdisciplinary Sciences
Department of Complexity Science and Engineering / / Biological Complex Systems
http://www.brain.k.u-tokyo.ac.jp/people/takeda/takeda-j.html

Career Summary
1977 Dr. Eng., Mathematical Engineering and Information Physics, Tokyo University
1978 Researcher at Industrial Products Research Institute, MITI
1993 Head of Division, National Institute of Bioscience and Human Technology, MITI
1997 Professor, Department of Complexity of Science and Engineering, Faculty of Frontier science, Tokyo University

Educational Activities
Graduate School: Brain Engineering
Undergraduate School: Biomedical Measurement

Research Activities
Elucidation of Human Higher Brain Functions using MEG (Magnetoencephalography)
Development of Helium Circulation Systems
Study of Visual Systems using TDO (Three-Dimensional Optometer)

Literature
1) Shimono M., Owaki T., Amano K., Kitajo K., Takeda T.: Functional modulation of power-law distribution in visual perception, Physical Review E, 75, 5, 1-5, 2007.
2) Takeda T., Okamoto M., Atsuda K., Kobayashi, A., Owaki, T., Katagiri K.: An efficient helium circulation system with small GM cryocoolers, Cryogenics, 47, 12, 833-838, 2007.
3) Nara T., Oohama J., Hashimoto M., Takeda T., Ando S.: Direct reconstruction algorithm of current dipoles for vector magnetoencephalography and electroencephalography, Physics in Medicine and Biology, 52, 3859-3879, 2007.
4) Amano, K., Goda, N., Nishida, S., Ejima, Y., Takeda, T., and Ohtani, Y.: Estimation of the timing of human visual perception from magnetoencephalography, Journal of Neuroscience, 26, 15, 3981-3991, 2006.
5) Amano, K., Nishida, S., Takeda, T.: MEG responses correlated with the visual perception of speed change, Vision Research, 46, 427-432, 2006.
6) Takeda T.: Brain Engineering, CORONA PUBLISHING CO. LTD., 2003 (in Japanese).
7) Takeda, T., Endo, H., Hashimoto, K. : Research on dynamic accommodation using TDOIII (Three-dimensional optometer III) and MEG (Magnetoencephalography): Accommodation and Vergence Mechanisms in the Visual System, 51-66, 2000.
8) Takeda, T., Hashimoto, K., Hiruma, N. and Fukui, Y.: Characteristics of accommodation evoked by apparent depth, Vision Research, 39, 12, 2087-2098, 1999.
9) Takeda, T., Fukui, Y., Ikeda, K., Iida T.: Three-dimensional optometer III, Applied Optics, 32, 22, 4155-4168, 1993.
10) Takeda, T., Neveu, C., Stark, L.: Accommodation on downward gaze, Optometry and Vision Science, 69, 7, 556-561, 1992.


Awards:
Agency of Science and Technology (1991)
Agency of Industrial Science and technology (1992)
Tsukuba City (1993)
Agency of Science and Technology for prominent patents (1988, 1991, 1994)
Japanese Biomechanism Association (2000)
Other Activities
Director, Japan Biomagnetism Society

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Future Plan
Recently, various non-invasive brain measurement apparatuses have been developed and paved the way for scientific study of the brain. Our laboratory mainly uses MEG (magnetoencephalography), which is the most sophisticated direct measurement method of brain cell functions. MEG can easily measure brain activity with 1 ms of temporal resolution and several mm of special resolution using SQUID (Super Conducting Quantum Interference Device), although the intensity of the magnetic field emitted from the brain cells is extremely weak (10-8 of the earth's magnetic field). Our laboratory has developed a 440-CH vector-type MEG system, which has the highest number of channels and is extremely useful for measuring vector signals of magnetic fields. We are now investigating advanced measurement techniques and novel brain functions, ranging from the basic audio-visual sensing properties to the linguistic properties, and how the “mind” is formed in the brain. Regarding measurement techniques, we are trying to determine whether vector measurement is superior to conventional MEGs, as well as investigate advanced methods to identify brain activity location and various experimental paradigms. We have developed the world’s first helium circulation system, which will be very valuable for future MEG proliferation, and also for the various systems utilizing superconductors. We are also aiming to develop a superfluid helium circulation system for future super-strong magnet applications.
One of the interesting laboratory research topics is the suggestion that brain alpha wave comes from a reset function coinciding with light and color information in the visual system, as transmission times from the retina to the brain are considerably different. We are now finding some intriguing MEG responses relating to the intentional control of perception of an ambiguous figure.
We have also developed a three-dimensional optometer (TDO), which is capable of measuring three basic ocular functions (accommodation, eye movement and pupil diameter) during real visual activities.
The main thrust of our laboratory is to elucidate dynamic information processing in the brain utilizing MEG and TDO.
Messages to Students
Our laboratory motto is ”open and challenge new research frontiers”.
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