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| Takeshi Wada / Associate Professor / Division of System Medical Sciences |
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Department of Medical Genome Sciences / / Organic Chemistry, Bioorganic Chemistry, Biomolecular Science
http://park.itc.u-tokyo.ac.jp/moldes/
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| Career Summary |
1986: BSc from Tokyo University of Science
1988: MSc from Tokyo Institute of Technology
1991: PhD from Tokyo Institute of Technology
1991: Assistant Professor, Tokyo Institute of Technology
1999: Associate Professor, The University of Tokyo
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| Educational Activities |
Graduate School: Biofunctional Organic Chemistry, Practice in Medical Genome Sciences
Undergraduate School: Organic Chemistry III, Supramolecular Chemistry, Organic Experiments
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| Research Activities |
Chemical synthesis of artificial biomolecules (1999-2007):
We have been studying about chemical synthesis of artificial biomolecules based on nucleic acids, carbohydrates, peptides and other physiologically active substances.
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Literature
1) Oka, N., Wada, T., Saigo, K. J. Am. Chem. Soc. 124, 4962-4963 (2002).
2) Suzuki, T., Suzuki, T., Wada, T., Saigo, K., Watanabe, K. EMBO J. 21, 6581-6589 (2002).
3) Oka, N., Wada, T., Saigo, K. J. Am. Chem. Soc. 125, 8308-8317 (2003).
4) Shimizu, M., Saigo, K., Wada, T. J. Org. Chem. 71, 4262-4269 (2006).
5) Watanabe, K., Toh, Y., Suto, K., Shimizu, Y., Oka, N., Wada, T., Tomita, K. Nature 449, 867-871 (2007).
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| Other Activities |
The Chemical Society of Japan
The Society of Synthetic Organic Chemistry, Japan
The Japanese Society of Carbohydrate Research
The Japanese Peptide Society
Antisense DNA/RNA Society
The Japanese Society of Fluorous Technology
International Society for Nucleosides, Nucleotides and Nucleic Acids
Center for NanoBio Integration, The University of Tokyo
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| Future Plan |
In recent years, a great deal of attention has been focused on small DNA and RNA molecules as therapeutic agents for selective inhibition of gene expression. Oligonucleotide therapeutic agents, such as antisense DNAs, ribozymes, siRNAs, and microRNAs, act on target mRNAs and arrest the protein synthesis. I wish to develop new artificial nucleic acids as therapeutic agents by a chemical approach.
Oligonucleotide therapeutic agents
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| Messages to Students |
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I simply hope you enjoy science at Kashiwa campus as much as you can!
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