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| Seiryo Sugiura / Professor / Division of Einvironmental Sciences |
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Department of Human and Engineered Environmental Studies / / Heart Simulation, Physiology of the Heart
http://www.sml.k.u-tokyo.ac.jp
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| Career Summary |
1975: Graduated, Faculty of Engineering, The University of Tokyo
1982: Graduated, Faculty of Medicine, The University of Tokyo
1982: Resident, The University of Tokyo Hospital
1984: Staff Cardiologist, The University of Tokyo Hospital
1985-87: Postdoctoral Fellow, Department of Biomedical Engineering, School of Medicine, Johns Hopkins University
1987-89: Cardiologist, JR Tokyo General Hospital
1989: Staff Cardiologist, The University of Tokyo Hospital
1995: Doctor of Medicine from The University of Tokyo
1995-2002: Assistant Professor, The University of Tokyo Hospital
2002: Professor, The University of Tokyo
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| Educational Activities |
Graduate school:Systems Physiology, Human Environment
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| Research Activities |
Our goal is to develop a multi-scale, multi-physics heart simulator, in which contraction of the heart and the resultant blood flow is driven by the molecular mechanism implemented in each finite element representing the cardiomyocytes. For this purpose, we are collecting missing information on the normal and abnormal functions of the heart from the molecular to organ levels. Shown in the figure is one of such effort, in which we measured the functional property of a single cardiomyocyte using our original experimental device (ref. 2). Such experimental works also serve to verify the accuracy of the heart simulator.
Single cell mechanics
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Literature
1) Nishimura S, Nagai S, Katoh M, Yamashita H, Saeki Y, Okada J-I, Hisada T, Nagai R, Sugiura S, Microtubules modulate the stiffness of cardiomyocytes against shear stress. Circ Res 98:81-87 (2006)
2) Sugiura S, Nishimura S, Yasuda SI, Hosoya Y, Katoh K, Carbon fiber technique for the investigation of single cell mechanics in intact cardiac myocytes. Nature Protocols 3:1453-1457 (2006)
3) Nishimura S, Nishimura M, Hosoya Y, Fujita H, Katoh M, Yamashita H, Manabe I, Tobe K, Kadowaki T, Nagai R, Sugiura S, Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells and blood vessels. Diabetes 56:1517-26 (2007)
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| Other Activities |
Japanese Society of Internal Medicine,
Japanese Circulation Society
Japanese College of Cardiology
Japanese Society for Medical and Biological Engineering
Fellow of the American Heart Association
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| Future Plan |
With further improvements in both software and hardware environments, the heart simulator can be an innovative tool in clinical cardiology.
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| Messages to Students |
The development of the heart simulator is made possible by the trans-disciplinary approach between the computational science and medicine and such attempts will open a new field of biological science.
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