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Manabu Watanabe / Associate Professor / Division of Biosciences
Department of Computational Biology and Medical Sciences / / Comparative molecular diagnosis and therapy
http://ssmgs.net/lab/

Career Summary
1997: Bachelor of Veterinary Science, Faculty of Agriculture, The University of Miyazaki
2001: Doctor of Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University
2001: Post-doctoral Fellow, The University of Tokyo
2004: Research Associate, The University of Tokyo
2005: Assistant Professor, The University of Tokyo
2007: Assistant Professor, The University of Tokyo
2014: Associate Professor, the University of Tokyo
2015: Associate Professor, the University of Tokyo

Educational Activities
Graduate school: Advanced Medical Genomics

Research Activities
Medical and molecular biology:
Elucidating antitumor and cell differentiating mechanisms of sodium phenylacetate and its application for drug discovery (1995-present)
Omics analysis of development and maturation of mammary tissues (2001-present)
Expression and functional analysis of novel breast cancer-related genes using Full-length cDNA data (2008-present)

Animal and veterinary sciences:
Multi-omics analysis of tumors in companion animals (2005-present)
Clinical trials of novel anticancer drugs for tumors in companion animals (2006-present)
Genome analysis in companion animals (2010-present)

Literature
(1) Saeki K., et al., Vet J. 2015 pii: S1090-0233:00167-7.
(2) Tomiyasu H., et al., Leuk Lymphoma. 2013 54:1309-15.
(3) Takeuchi Y., et al., J Vet Pharmacol Ther. 2012 35:97-104.
(4) Watanabe, M., et al. Breast Cancer Res. Treat. 2009 118: 281-291.

Other Activities
Japanese Society of Veterinary Science
The Japanese Cancer Association
Japanese Society of Animal Breeding and Genetics
Genome Network
Japanese Society of Pet Animal Nutrition

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Future Plan
In my research to date, I have developed and established an analysis platform for use in molecular pathological analysis of cancer, measurement of the effects of anticancer drugs, and drug discovery and development in the medical field, as well as companion animal genome research in veterinary medicine. On the basis of the big data obtained from this research, I would like to construct a comparative multi-translational research system incorporating horizontal and vertical integration of academic disciplines such as genomics, life sciences, medicine, zoology, veterinary medicine, and information science to elucidate the causes of life phenomena, traits, and diseases in the application, exploration, and development of molecular ecology, natural history, diagnostics, and therapeutics.

Messages to Students
I once heard the following from a teacher: "The relationship between research and researchers is like that between horses and horse trainers, as per the ancient Chinese proverb: ePotentially excellent horses aren't uncommon. What is rare is an excellent horse trainer.' That is, although the truth of phenomena is always present, correctly discerning the truth cannot be achieved overnight but rather requires a heart for constant inquiry, conscientious effort, and an unwavering spirit. The ultimate example of this is the demeanor of the sculptor Unkei, a character in the short story 'Ten Nights of Dreams' by Soseki Natsume. However, unlike a horse trainer who discovers a fine horse, a researcher must newly create on the basis of correctly discovered truth. The application of this knowledge is limitless-whether making roads or bridges or machines using new materials or methods; discovering diagnoses of diseases and medicines; or producing information infrastructure that links together the world and space-and should contribute to happiness in the lives of people around the world. What horse trainers and researchers have in common is that, even as they undergo numerous failures in the process of trial and error, they are both required to temper their own ability to think and to make correct judgments by constantly learning. You too will be engulfed in a whirlpool of information, and I hope you will place importance on the sense and balance that enables the correct discrimination of what is right, even as you are inundated with all of this information."
Although I have yet to reach this lofty standard, these words struck a deep chord within my youthful self many years ago, and for this reason I have chosen to include them in my message. I hope to come as close to living up to this ideal as I can.


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