| Career Summary |
1986: BSc, Faculty of Pharmaceutical Sciences (University of Tokyo)
1991: PhD (University of Tokyo)
1991-93: Research Fellow (Japan Society for the Promotion of Science)
1993-95: International Fellow for Immunology Laboratory (Harvard Medical School)
1995: Lecturer (Showa University)
1997: Associate Professor (Showa University)
2005-10: Project Leader, Biomembrane Project (Tokyo Metropolitan Institute of Medical Science)
2005-08: Research Fellow (JST PRESTO)
2010-present: Project Leader, Lipid Metabolism Project (Tokyo Metropolitan Institute of Medical Science)
|
 |
|
|
| Educational Activities |
Graduate school: System Cell Biology
Tokyo Medical and Dental University: Regulation of Cell and Tissue Development
Kitazato University
Niigata University Graduate School of Medical and Dental Sciences
Ochanomizu University
|
|
|
|
| Research Activities |
Clarifying biological functions of phospholipase (PLA2) enzymes and their lipid products in various diseases (metabolic syndrome, atherosclerosis, allergies, and so on) using knockout and transgenic mice.
Analysis of PLA2s and their lipid products in pathophysiology
|
Literature
1) Yamamoto, K., Taketomi, T., Isogai, Y., Miki, Y., Sato, H., Masuda, S., Nishito, Y., Morioka, K., Ishimoto, Y., Suzuki, N., Yokoya, Y., Hanasaki, K., Ishikawa, Y., Ishii, T., Kobayashi, T., Fukami, K., Ikeda, K., Nakanishi, H., Taguchi, R., and Murakami, M. (2011) Hair follicular expression and function of group X secreted phospholipase A2 in mouse skin. J. Biol. Chem. 286, 11616-11631
2) Sato, H., Isogai, Y., Masuda, S., Taketomi, Y., Miki, Y., Kamei, D., Hara, S., Kobayashi, T., Ishikawa, Y., Ishii, T., Ikeda, K., Taguchi, R., Ishimoto, Y., Suzuki, N., Yokota, Y., Hanasaki, K., Suzuki-Yamamoto, T., Yamamoto, K., and Murakami, M. (2011) Physiological roles of group X secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function. J. Biol. Chem. 286, 11632-11648
3) Sato, H., Taketomi, T., Isogai, Y., Miki, Y., Yamamoto, K., Masuda, S., Hosono, T., Arata, S., Ishikawa, Y., Ishii, T., Kobayashi, T., Nakanishi, H., Ikeda, K., Taguchi, R., Hara, S., Kudo, I., and Murakami, M. (2010) Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice. J. Clin. Invest. 120, 1400-1414
4) Escoffier, J., Jemel, I., Tanemoto, A., Taketomi, Y., Payre, C., Coatrieux, C., Sato, H., Yamamoto, K., Masuda, S., Pernet-Gallay, K., Pierre, V., Hara, S., Murakami, M., De Waard, M., Lambeau, G., and Arnoult, C. (2010) Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice. J. Clin. Invest. 120, 1415-1428
5) Sato, H., Kato, R., Isogai, Y., Saka, G., Ohtsuki, M., Taketomi, Y., Yamamoto, K., Tsutsumi, K., Yamada, J., Masuda, S., Ishikawa, Y., Ishii, T., Kobayashi, T., Ikeda, K., Taguchi, R., Hatakeyama, S., Hara, S., Kudo, I., Itabe, H., and Murakami, M. (2008) Analyses of group III secreted phospholipase A2 transgenic mice reveals potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis. J. Biol. Chem. 283, 33483-33497
|
|
|
|
| Other Activities |
The Japanese Biochemistry Society
The Japanese Lipid Biochemistry Society
The Japanese Society of Inflammation and Regeneration
The Pharmaceutical Society of Japan
American Society for Biochemistry and Molecular Biology (ASBMB)
|
|
|
|
| Future Plan |
We aim to clarify the whole picture of PLA2-mediated lipid metabolism in health and diseases.
|
|
|
|
| Messages to Students |
Let's investigate the biomedical science world of lipids together.
I hope that you will join us in our mission to revive the importance of knowledge, bridge knowledge gaps in modern society, and create a global learning and research environment for the next generation.
|
|
|
|
 |
|
