Koichi Matsuda / Professor / Division of Biosciences
Department of Computational Biology and Medical Sciences / / Genome Science

Career Summary
1994 Obtained M.D. from the University of Tokyo.
1994-1999 Department of Orthopaedic Surgery, University of Tokyo
1999-2003 Graduate Sschool of Nedicine, University of Tokyo.
2003-2004 Postdoctoral Research Fellowship Baylor College of Medicine,
2004-2009 Assistant Professor University of Tokyo
2009-2015 Associate Professor University of Tokyo
2015-present Professor University of Tokyo

Educational Activities
Graduate school:Genome science
Research Activities
Identification of novel p53 targets (1999-)
Genome wide association study (2007-)
Genome analysis of rare cancer (2014-)

[1] K. Matsuda, K. Yoshida, Y. Taya, K. Nakamura, Y. Nakamura, and H. Arakawa, p53AIP1 regulates the mitochondrial apoptotic pathway, Cancer Res, 62 (2002) 2883-2889.
[2] C. Tanikawa, K. Matsuda, S. Fukuda, Y. Nakamura, and H. Arakawa, p53RDL1 regulates p53-dependent apoptosis, Nat Cell Biol, 5 (2003) 216-223.
[3] X. Yang, K. Matsuda, P. Bialek, S. Jacquot, H.C. Masuoka, T. Schinke, L. Li, S. Brancorsini, P. Sassone-Corsi, T.M. Townes, A. Hanauer, and G. Karsenty, ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome, Cell, 117 (2004) 387-398.
[4] C. Tanikawa, K. Ueda, H. Nakagawa, N. Yoshida, Y. Nakamura, K. Matsuda, Regulation of protein Citrullination through p53/PADI4 network in DNA damage response, Cancer Res, 69 (2009) 8761-8769.
[5] R. Cui, Y. Kamatani, A. Takahashi, M. Usami, N. Hosono, T. Kawaguchi, T. Tsunoda, N. Kamatani, M. Kubo, Y. Nakamura, and K. Matsuda, Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk, Gastroenterology, 137 (2009) 1768-1775.
[6] Y. Kamatani, S. Wattanapokayakit, H. Ochi, T. Kawaguchi, A. Takahashi, N. Hosono, M. Kubo, T. Tsunoda, N. Kamatani, H. Kumada, A. Puseenam, T. Sura, Y. Daigo, K. Chayama, W. Chantratita, Y. Nakamura, and K. Matsuda, A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians, Nat Genet, 41 (2009) 591-595.
[7] Y. Kamatani, K. Matsuda, Y. Okada, M. Kubo, N. Hosono, Y. Daigo, Y. Nakamura, and N. Kamatani, Genome-wide association study of hematological and biochemical traits in a Japanese population, Nat Genet, 42 (2010) 210-215.
[8] V. Kumar, N. Kato, Y. Urabe, A. Takahashi, R. Muroyama, N. Hosono, M. Otsuka, R. Tateishi, M. Omata, H. Nakagawa, K. Koike, N. Kamatani, M. Kubo, Y. Nakamura, and K. Matsuda, Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma, Nat Genet, 43 (2011) 455-458.
[9] C. Tanikawa, Y. Urabe, K. Matsuo, M. Kubo, A. Takahashi, H. Ito, K. Tajima, N. Kamatani, Y. Nakamura, and K. Matsuda, A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population, Nat Genet, 44 (2012) 430-434, S431-432.
[10] C. Tanikawa, M. Espinosa, A. Suzuki, K. Masuda, K. Yamamoto, E. Tsuchiya, K. Ueda, Y. Daigo, Y. Nakamura, and K. Matsuda, Regulation of histone modification and chromatin structure by the p53-PADI4 pathway, Nature communications, 3 (2012) 676.
[11] K. Matsuda, A. Takahashi, C.D. Middlebrooks, W. Obara, Y. Nasu, K. Inoue, K. Tamura, I. Yamasaki, Y. Naya, C. Tanikawa, R. Cui, J.D. Figueroa, D.T. Silverman, N. Rothman, M. Namiki, Y. Tomita, H. Nishiyama, K. Kohri, T. Deguchi, M. Nakagawa, M. Yokoyama, T. Miki, H. Kumon, T. Fujioka, L. Prokunina-Olsson, M. Kubo, Y. Nakamura, and T. Shuin, Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population, Hum Mol Genet, 24 (2015) 1177-1184.

Other Activities
Japan Cancer Association, The Japan Society of Human Genetics, American Association of Cancer Research,
Cancer Science (Associate editor), Journal of Human Genetics (Associate editor)
Future Plan
The goal of our laboratory is to translate basic science and genome research into clinical practice. For this purpose, we try to identify biomarkers that are useful for the prediction of disease risk, drug response, and clicinal decision.

Messages to Students
In general, new Ph.D students will start a project related to the p53 pathway and learn basic experimental skills. Our laboratory also manages a large disease cohort called Biobank Japan that contains more than 200,000 DNA and serum samples of 51 common diseases, and student will have the oppotunity to work on big projects related to this.