Kazuhiro Nakayama / Associate Professor / Laboratory of Evolutionary Anthropology
Department of Integrated Biosciences / / Human Evolutionary Genetics

Career Summary
1999: Graduated from the Tokai Universiy,School of High-Technology for Human Welfare
2004: Received Ph.D. in Science from University of Tokyo
2004: JSPS Postdoctoral Fellow (University of Tokyo)
2005: 21th Century COE Program Research Fellow (University of Tokyo)
2006: Research Associate (Jichi Medical University)
2013: Assistant Professor (Jichi Medical University)
2017: Associate Professor (University of Tokyo)
Educational Activities
Human Genetics (School of Medicine, Jichi Medical University)
Anthropology (Utsunomiya Dental Hygienist College)
Biochemistry (Maronie Collage of Health & Welfare Sciences)
Research Activities
1. Genome and epigenome diversity of Mongolians and other East Asians
2. Evolutionary genetics of life-style related diseases in modern humans
1)Nakayama K., Ohashi J., Watanabe K., Munkhtulga L., and Iwamoto S. Evidence for Very Recent Positive Selection in Mongolians. Mol Biol Evol. 2017 published online.
2)Nakayama K. and, Iwamoto S. An adaptive variant of TRIB2, rs1057001, is associated with higher expression levels of thermogenic genes in human subcutaneous and visceral adipose tissues. J Phyiol Anthropol. 2917 36:16
3)Nakayama K., Saito S., Watanabe K., Miyashita H., Nishijima F., Kamo Y., Tada K., Ishizuka S., Niwa T., Iwamoto S., and Shimizu H . Influence of AHRR Pro189Ala polymorphism on kidney functions. Biosci Biotech Biochem. 2017 Published online.
4)Nakayama K., Watanabe K., Boonvisut S., Makishima S., Miyashita H., and Iwamoto S. Common variants of GIP are associated with visceral fat accumulation in Japanese adults. Am J Physiol Gastrointest Liver Physiol. 2014 307: G1108-14.
5)Nakayama K., Miyashita H., and Iwamoto S. Seasonal effects of the UCP3 and the RPTOR gene polymorphisms on obesity traits in Japanese adults. J Physiol Anthropol. 2014 33:38.
6)Nakayama K., Ogawa A., Miyashita H., Tabara Y., Igase M., Kohara K., Miki T., Kagawa Y., Yanagisawa Y., Katashima M., Onda T., Okada K., Fukushima S., and Iwamoto S. Positive natural selection of TRIB2, a novel gene that influences visceral fat accumulation, in East Asia. Hum Genet. 2013 132:201-17.
7)Nakayama K., Miyashita H., Yanagisawa Y., and Iwamoto S. Seasonal effects of UCP1 gene polymorphism on visceral fat accumulation in Japanese adults. PLoS One. 2013 8:e74720.
8)Nakayama K., Yanagisawa Y., Ogawa A., Ishizuka Y., Munkhtulga L., Charupoonphol P., Supannnatas S., Kuartei S., Chimedregzen U., Koda Y., Ishida T., Kagawa Y., and Iwamoto S. High prevalence of an anti-hypertriglyceridemic variant of the MLXIPL gene in Central Asia. J Hum Genet. 2011 56:828-33.
9)Nakayama K., Bayasgalan T., Tazoe F., Yanagisawa Y., Gotoh T., Yamanaka K., Ogawa A., Munkhtulga L., Chimedregze U., Kagawa Y., Ishibashi S., and Iwamoto S; Jichi Medical University Promotion Team of a Large-Scale Human Genome Bank for All Over Japan. A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle. Hum Genet. 2010 127:685-90.
10)Nakayama K., Shotake T., Takeneka O., and Ishida T. Variations in the Coding Region of the Agouti Signaling Protein Gene Do Not Explain Agouti/Non-agouti Phenotypes in Macaques. J Mammal Evol. 2010 17:211-4.
11)Nakayama K., Bayasgalan T., Yamanaka K., Kumada M., Gotoh T., Utsumi N., Yanagisawa Y., Okayama M., Kajii E., Ishibashi S., and Iwamoto S; Jichi Community Genetics Team (JCOG). Large scale replication analysis of loci associated with lipid concentrations in a Japanese population. J Med Genet. 2009 46:370-4.
12)Nakayama K., Shotake T., Takeneka O., and Ishida T. Variation of the melanocortin 1 receptor gene in the macaques. Am J Primatol. 2008 70:778-85.
13)Nakayama K., Lkhagvasuren M., Yanagisawa Y., Utsumi N., Kumada M., Gotoh T., Iwamoto S., and Kagawa Y. Comparative study of polymorphisms on genes associated with lifestyle related diseases in Asian and Pacific populations. Asia Pac J Public Health. 2008 20:S173-9.
14)Nakayama K. and, Ishida T. Alu-mediated 100-kb deletion in the primate genome: The loss of the agouti signaling protein gene in the lesser apes. Genome Res. 2006 16:485-90.
15)Nakayama K., Soemantri A., Jin F., Dashnyam B., Ohtsuka R., Duanchang P., Isa M.N., Settheetham-Ishida W., Harihara S., and Ishida T. Identification of novel functional variants of the melanocortin 1 receptor gene originated from Asians. Hum Genet. 2006 119:322-30.
16)Nakayama K., Fukamachi S., Kimura H., Koda Y., Soemantri A., and Ishida T. Distinctive distribution of AIM1 polymorphism among major human populations with different skin color. J Hum Genet. 2002 47:92-4.
Other Activities
Anthropological Society of Nippon
Japan Society of Physiological Anthropology
Japan Society of Nutrition and Food Science
Japan Society of the Study of Obesity
The Japan Society of Human Genetics

Future Plan
Our laboratory has just started from July 2017. We are going to undertake research into the molecular evolutionary genetics of human phenotypic diversity.

Messages to Students
We welcome students eager to learn about human biology and evolution. Please do not hesitate contact us.