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Katsuya Tsuchihara / Associate Professor / Division of Cancer Biology
Department of Integrated Biosciences / / Cancer Genomics, Cancer Metabolism, Translational Research
http://epoc.ncc.go.jp/about/staff/tsuchihara.php

Career Summary
1993: Graduated from School of Medicine (Kanazawa University)
2000: Received Ph.D. in Medicine from Tokyo Medical and Dental University
2000: Postdoctoral Fellow (Ontario Cancer Institute, University of Toronto)
2005: Head, Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East
2011: Visiting Associate Professor (University of Tokyo)
2012: Chief, Division of Translational Research, Research Center for Innovative Oncology, National Cancer Center Hospital East
2013: Chief, Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center
Educational Activities
Activities Breakthrough Now and Then I, Seminar in Integrated Biosciences, Advanced Seminar in Integrated Biosciences, Research of Integrated Biosciences I, II
Research Activities
High-resolution genome-wide analyses of cancer genomics (2010-present):We aim to define the mutational landscape of the cancer genome by next-generation sequencing to trace the evolution of individual cancers. We also explore novel biomarkers based on comprehensive genomic and epigenomic analyses useful to predict the prognosis of patients and therapeutic effects of anticancer therapies.
Literature
Tsuchihara K, Suzuki Y, Wakaguri H, Irie T, Tanimoto K, Hashimoto S, Matsushima K, Mizushima-Sugano J, Yamashita R, Nakai K, Bentley D, Esumi H and Sugano S: Massive transcriptional start site analysis of human genes in hypoxia cells, Nucleic Acids Res Vol. 37, No. 7, pp. 2249-2263, Apr. 20092) Kawamoto Y, Tsuchihara K, Yoshino T, Ogasawara N, Kojima M, Takahashi M, Ochiai A, Bando H, Fuse N, Tahara M, Doi T, Esumi H, Komatsu Y and Ohtsu A: KRAS mutations in primary tumours and post-FOLFOX metastatic lesions in cases of colorectal cancer, Br J Cancer Vol. 107, No. 2, pp. 340-344, Jul. 2012
Other Activities
Councilor, Japanese Cancer Association (JCA)Member, The Molecular Biology Society of Japan (MBSJ)Member, AmericanAssociation for Cancer Research (AACR)
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Future Plan
Clarifying biological mechanisms dominating cancer cells and their microenvironment by comprehensive genome and epigenome analyses to achieve individualized precision medicine of cancer.
Messages to Students
Close collaboration between basic and clinical sciences is necessary to conquer cancer. Ambitious young researchers with diverse backgrounds are very welcome to our team.
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