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Hitoshi Satoh / Associate Professor / Biosciences Division
Department of Computational Biology and Medical Sciences / / Molecular cytogenetics
http://www.ims.u-tokyo.ac.jp/ltcb-mgs

Career Summary
1978: BSc, Faculty of Science, Hirosaki University
1983: MSc, Faculty of Science, Hokkaido University
1986: PhD, Faculty of Science, Hokkaido University
19861987: Postdoctoral Fellow, Fellowships of the Japan Society for the Promotion of Science for Japanese Junior Scientists
1987-1990: Visiting Fellow, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
1990-2004: Research Associate, Division of Pathology, Department of Cancer Biology, The Institute of Medical Sciences, The University of Tokyo
2004-present: Associate Professor, Laboratory of Tumor Cell Biology, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo
Educational Activities
Graduate school: Basics of Pathophysiology and Medical Therapy

Nippon Veterinary & Life Science University (Lecturer):
Genetic Engineering (II)
Research Activities
1) Screening of the tumor suppressor genes by a microcell-mediated chromosome transfer system:Introduction of normal human chromosomes 3 and 11
into A549 lung adenocarcinoma cell line have showed the suppression of
tumorigenicity, but not the introduction of chromosome 7 (1).
2) Gene mapping in humans and several laboratory animals: Over 80 genes
were mapped, and comparative mapping has revealed the conservation of
syntenic groups of genes along with extensive homologies of chromosome
banding patterns (4).
3) Molecular cytogenetics in the domestic cat: Establishment of the chromosome nomenclature of the domestic cat (2). Assignment of the cat
immunoglobulin and T-cell receptor genes and determination of the
integration sites of FeLV genomes in cat lymphoid tumor cell lines by
FISH and Southern blot analyses (5).
4) Cloning of genes responsible for reciprocal chromosome
translocation: Intronic U50 snoRNA host gene has been mapped at the
chromosome breakpoint t(3;6)(q27;q15) of human B-cell lymphoma.
Literature
1) Satoh, H., Lamb, P. W., Dong, J. T., Everitt, J., Boreiko, C., Oshimura, M. and Barrett, J. C.: Suppression of tumorigenicity of A549 lung adenocarcinoma cells by human chromosomes 3 and 11 introduced via microcell-mediated chromosome transfer. Mol. Carcinogenesis 7: 157-164 (1993).
2) Cho, K. W., Youn, H. Y., Watari, T., Tsujimoto, H., Hasegawa, A. and Satoh, H.: A proposed nomenclature of the domestic cat karyotype. Cytogenet. Cell Genet. 79: 71-78 (1997).
3) Tanaka, R., Satoh, H., Moriyama, M., Satoh, K., Morishita, Y., Yoshida, S., Watanabe, T., Nakamura, Y. and Mori, S.: Intronic U50 small nucleolar RNA(snoRNA) host gene of no protein-coding potential is mapped at the chromosome breakpoint t(3;6)(q27;q15) of human B-cell lymphoma. Genes to Cells 5:277-287 (2000).
4) Satoh, H., Fujiwara, M., Fukami, T., Fukuhara, H. and Murakami, Y.: Comparative assignments of the TSLC1 and TSLC1-like tumor suppressor genes, TSLL1 and TSLL2, to rat chromosomes by fluorescence in situ hybridization. Bull. Nippon Vet. Anim. Sci. Univ. 52: 24-28 (2003).
5) Fujino, Y., Satoh, H., Hisasue, M., Masuda, K., Ohno, K. and Tsujimoto, H.: Detection of the integrated feline leukemia viruses in a cat lymphoid tumor cell line by fluorescence in situ hybridization. J. Hered. 94: 251-255 (2003).
6) Zhang, X., Soda, Y., Takahashi, K., Bai, Y., Mitsuru, A., Igura, K., Satoh, H., Yamagchi, S., Tani, K., Tojo, A. and Takahashi, T.: Successful immortalization of mesenchymal progenitor cells derived from human placenta and the differentiation abilities of immortalized cells. Biochem. Biophy. Res. Commun. 351: 853-859 (2006).
7) Tanaka-Fujita, R., Soeno, Y., Satoh, H., Nakamura, Y. and Mori, S.: Human and mouse protein-noncoding snoRNA host genes with dissimilar nucleotide sequences show chromosomal synteny. RNA 13: 811-816 (2007).
8) Yokomi, I., Tanaka, M., Kobayashi, S., Takahashi, T., Sudo, K. and Satoh, H.: Trisomy of rat chromosome 1 in haematopoietic cell lineages may cause an early-onset of paraplegia. Bull. Nippon Vet. Life Sci. Univ. 59: 51-57 (2010).
9) Ogiwara, H., Ui, A., Otsuka, A., Satoh, H., Yokomi, I., Nakajima, S., Yasui, A., Yokota, J. and Kohno, T.: Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors. Oncogene 30: 2135-2146 (2011).
10) Yokomi, I., Ogiwara, H., Kohno, T., Yokota, J. and Satoh, H.: Two color fluorescence in situ hybridization analysis of the transfected plasmid DNA in human lung cancer cell line, H1299. Cytologia 78: 121-122 (2013).

SKY-FISH
SKY-FISH

Other Activities
The Society of Chromosome Research (Councilor)
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Future Plan
Investigating the pathophysiological causation of diseases based on the specific chromosome abnormality found in each malignant lymphoma. Especially focusing on the gene amplification occurring in several tumors.


Messages to Students
I hope you find your own theme during your graduate school days. It'll be tough to resolve a given subject completely within a short period of time. What is important? Never quit when facing knotty missions, keep pushing forward, and improve your skills, I believe. Enjoy your research in the field of life science.
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