Hideki Sezutsu / Professor / Division of Biosciences
Department of Integrated Biosciences / / Insect design, Basic sciences and applications using transgenic silkworms

Career Summary
1990: Graduated from the Faculty of Science, University of Kyushu
1996: Postdoctoral Scientist, National Institute of Sericultural and Entomological Science
1997: Received Ph.D from University of Kyushu
2001: Research Scientist, RIKEN Genomic Sciences Center
2004: Research Scientist (Fixed-term), National Institute of Agrobiological Sciences
2006-2007: Research Scientist, INRA, France (Concurrent Position)
2009: Research Scientist, National Institute of Agrobiological Sciences
2010: Head, Transgenic Silkworm Research Unit, National Institute of Agrobiological Sciences
2013: Professor, University of Tokyo (Concurrent Position)
Educational Activities
Graduate School: Applied Bioresource Sciences
Research Activities
1) Evolution of the LINE-like retrotransposon I element in Drosophila (1990-1996).
2) Evolution of silk genes in insects (1996-2000, 2004-present).
3) SNP discovery and mutant analysis in the mouse ENU mutagenesis (2001-2004).
4) Genome synteny analysis among lepidopteran species (2006-2007).
5) Basic sciences and applications using transgenic silkworms (2004-present).
1) Sezutsu H, Nitasaka E, and Yamazaki T. Evolution of the LINE-like retrotransposon I element in the Drosophila melanogaster species group. Molecular and General Genetics 249:168-178 (1995).
2) Sezutsu H and Yukuhiro K. Dynamic rearrangement within the Antheraea pernyi silk fibroin gene is associated with four types of repetitive units. Journal of Molecular Evolution, 51(4):329-338 (2000).
3) Sakuraba Y, Sezutsu H, Takahasi KR, Tsuchihashi K, Ichikawa R, Fujimoto N, Kaneko S, Nakai Y, Uchiyama M, Goda N, Motoi R, Ikeda A, Karashima Y, Inoue M, Kaneda H, Masuya H, Minowa O, Noguchi H, Toyoda A, Sakaki Y, Wakana S, Noda T, Shiroishi T, and Gondo Y. Molecular characterization of ENU mouse mutagenesis and archives. Biochemical and Biophysical Research Communications 336(2):609-616 (2005).
4) d'Alencon E*, Sezutsu H*, Legeai F, Permal E, Bernard-Samain S, Gimenez S, Gagneur C, Cousserans F, Shimomura M, Brun-Barale A, Flutre T, Couloux A, East P, Gordon K, Mita K, Quesneville H, Fournier P, and Feyereisen R. Extensive synteny conservation of holocentric chromosomes in Lepidoptera despite high rates of local genome rearrangement. Proceedings of the National Academy of Sciences of the United States of America 107(17):7680-7685 (2010).
5) Osanai-Futahashi M, Ohde T, Hirata J, Uchino K, Futahashi R, Tamura T, Niimi T, and Sezutsu H. A visible dominant marker for insect transgenesis. Nature communications 3:1295 (2012).

Other Activities
The Japanese Society of Sericultural Science
The Japanese Society for Wild Silkmoths
International Society for Wild Silkmoths
The Genetic Society of Japan
The Molecular Biology Society of Japan
Future Plan
We are developing transgenic silkworms for fundamental research and applications. Our aims are to understand insect functions and to design the insects for the creation of new insect-industries.
Messages to Students
Insects are diversified, but many biological functions are still unknown and remain unused. Our research areas are extensive to enable broad understanding and the use of insect functions. Our laboratory is located in Tsukuba and we have many insect researchers who can be engaged in discussion. We welcome graduate students who have passion, ideas and the drive.