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Computational Biology And Medical Sciences

Title
Date
Long read sequencing for non-small cell lung cancer genome 2020:09:06:15:08:16
AbstractHere, we report the application of a long-read sequencer, PromethION, for analyzing human cancer genomes. We first conducted whole-genome sequencing on lung cancer cell lines. We found that it is possible to genotype known cancerous mutations, such as point mutations. We ...
 
September 6, 2020
Chromosomal alterations among age-related haematopoietic clones in Japan 2020:06:25:9:42:20
AbstractThe extent to which the biology of oncogenesis and ageing are shaped by factors that distinguish human populations is unknown. Haematopoietic clones with acquired mutations become common with advancing age and can lead to blood cancers1,2,3,4,5,6,7,8,9,10. Here we describ...
 
June 25, 2020
Large-scale genome-wide association study across different diseases in a Japanese population 2020:06:09:9:52:06
AbstractThe overwhelming majority of participants in current genetic studies are of European ancestry. To elucidate disease biology in the East Asian population, we conducted a genome-wide association study (GWAS) with 212,453 Japanese individuals across 42 diseases. We detected ...
 
June 9, 2020
Prevalence of pathogenic germline variants with early-onset colorectal, breast, and prostate cancer 2020:04:09:14:00:38
AbstractPUPOSEWe investigated the prevalence and spectrum of pathogenic germline variants in patients with early-onset colorectal cancer (CRC), breast cancer (BC), and prostate cancer (PCA) in the Japanese population. We also identified pathogenic variants in other cancer risk ge...
 
April 9, 2020
Trans-biobank analysis elucidates the association of polygenic risk scores with human lifespan. 2020:03:24:16:57:48
AbstractWhile polygenic risk scores (PRSs) are poised to be translated into clinical practice through prediction of inborn health risks, a strategy to utilize genetics to prioritize modifiable risk factors driving heath outcome is warranted. To this end, we investigated the assoc...
 
March 24, 2020
February 27, 2020
Essential role of the Crk family-dosage in DiGeorge-like anomaly and metabolic homeostasis 2020:02:12:12:52:07
AbstractCRK and CRKL (CRK-like) encode adapter proteins with similar biochemical properties. Here, we show that a 50% reduction of the family-combined dosage generates developmental defects, including aspects of DiGeorge/del22q11 syndrome in mice. Like the mouse homologs of two 2...
 
February 12, 2020
Phase separation organizes the site of autophagosome formation 2020:02:06:9:17:08
AbstractMany biomolecules undergo liquid–liquid phase separation to form liquid-like condensates that mediate diverse cellular functions. Autophagy is able to degrade such condensates using autophagosomes—double-membrane structures that are synthesized de novo at the pre-autophag...
 
February 6, 2020
GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits 2020:02:03:14:35:20
AbstractDietary habits are important factors in our lifestyle, and confer both susceptibility to and protection from a variety of human diseases. We performed genome-wide association studies for 13 dietary habits including consumption of alcohol (ever versus never drinkers and dr...
 
February 3, 2020
Liquidity is a critical determinant for selective autophagy of protein condensates 2020:01:29:12:58:12
SummaryClearance of biomolecular condensates by selective autophagy is thought to play a crucial role in cellular homeostasis. However, the mechanism underlying selective autophagy of condensates and whether liquidity determines a condensate’s susceptibility to degradation by aut...
 
January 29, 2020
Targeting Excessive EZH1 and EZH2 Activities for the Epigenetic Abnormality of Malignant Lymphomas 2019:11:20:9:41:05
Highlights・Lymphoma transcriptome is under control of global H3K27me3 accumulation・EZH1 and EZH2 are druggable targets in EZH2WT/WT and EZH2WT/Mu malignancies・Inactivation of chromatin-associated genes triggers EZH1/2 perturbation・Targeting epigenome for pre-cancerous states is a...
 
November 20, 2019
GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation 2019:10:18:9:00:14
AbstractMosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing men. However, the genetic architecture and biological mechanisms underlying mLOY are not fully understood. In a cohort of 95,380 Japanese men, we identify 50 independent genetic markers ...
 
October 18, 2019
Characterizing rare and low-frequency height-associated variants in the Japanese population 2019:10:02:14:16:25
AbstractHuman height is a representative phenotype to elucidate genetic architecture. However, the majority of large studies have been performed in European population. To investigate the rare and low-frequency variants associated with height, we construct a reference panel (N = ...
 
October 2, 2019
New susceptibility loci for prostate cancer identified by genome-wide association study 2019:09:30:17:42:00
Genome-wide association studies (GWAS) have identified ~170 genetic loci associated with prostate cancer (PCa) risk, but most of them were identified in European populations. We here performed a GWAS and replication study using a large Japanese cohort (9,906 cases and 83,943 male...
 
September 30, 2019
Numerical operations in living cells by programmable RNA devices 2019:08:22:10:00:36
細胞内の複数のマイクロRNAを同時に検知して 細胞を生きたまま精密に分けることに成功 ポイントメッセンジャーRNA(mRNA)注1)を細胞内に導入することで、一度に複数の細胞内マイクロRNA(miRNA)注2)を検知し、生きた細胞で多変量解析注3)を実行することができた。細胞によって発現量が異なる複数のmiRNAを同時に検出することで、細胞の種類や分化段階に応じて細胞を分画することに成功した。 要旨遠藤慧助教(東京大学大学院新領域創成科学研究科)、齊藤博英教授(京都大学CiRA未来生命科学開拓部門)らの研究グループは、人工RNAを細胞に...
 
August 22, 2019
February 7, 2019
December 6, 2018
December 5, 2018
Autonomous gene expression control nanodevice will contribute to medical care 2018:08:20:13:36:17
Osaka University-led Japanese scientists construct integrated gene logic-chips called “gene nanochips”Gene expression is a fundamental of life, where each cell switches on and off specific genes. Thus, an autonomous device that could control the on-off switching would have great ...
 
August 20, 2018
Dean’s Award for Outstanding Achievement, Graduate School of Frontier Sciences 2018 2018:04:13:10:59:02
The recipients of the Dean's Award for Outstanding Achievement (Master course 12 students, Doctoral course 11 students) GSFS 2018 were announced. The awards were initiated in 2006 for the purpose of recognizing students and groups for outstanding achievement in academic learning, international exchange, and regional contribution. A ceremony was held on Wednesday March 14, and Dean Hiroshi Mitani awarded plaques to the recipients.
 
April 13, 2018
Dean’s Award for Outstanding Achievement, Graduate School of Frontier Sciences 2017 2017:03:30:11:49:58
The recipients of the Dean's Award for Outstanding Achievement (Master course 12 students, Doctoral course 12 students) GSFS 2017 were announced. The awards were initiated in 2006 for the purpose of recognizing students and groups for outstanding achievement in academic learning, international exchange, and regional contribution. A ceremony was held on Wednesday March 15, and Dean Takashi Mino awarded plaques to the recipients.
 
March 30, 2017
Commencement of First-in-Human Clinical Trial for New Molecular Targeting Drug 2016:04:07:22:22:57
TOKYO, Japan (March 22, 2016) –The National Cancer Center, The University of Tokyo, and Daiichi Sankyo Company, Limited (hereafter, Daiichi Sankyo) today announced a collaboration to develop a histone methylation enzyme EZH1/2 dual inhibitor (DS-3201), as a new molecular targeting agent for hematologic malignancy, and the commencement of Phase 1 clinical trial in patients with malignant lymphoma and adult T-cell leukemia-lymphoma (ATL).
 
April 7, 2016
August 17, 2015
August 17, 2015
Visualizing RNAi at work 2015:07:03:9:27:23
University of Tokyo and Kyoto University researchers have revealed the molecular mechanism of RNA interference (RNAi), the phenomenon by which the synthesis of a specific protein is inhibited, by real time observation of target RNA cleavage at the single-molecule level.
 
July 3, 2015