Science

Title
Date
Low-voltage and high-mobility organic single-crystal transistors made by polymer-blend printing 2020:08:05:15:33:23
AbstructOrganic field-effect transistors (OFETs) have attracted great attention as key elements in Internet-of-Thing (IoT) devices due to their advantages of low cost and mass producibility made possible by printing technology. Such devices require organic semiconductors (OSCs) t...
 
August 5, 2020
Prevalence of pathogenic germline variants with early-onset colorectal, breast, and prostate cancer 2020:04:09:14:00:38
AbstractPUPOSEWe investigated the prevalence and spectrum of pathogenic germline variants in patients with early-onset colorectal cancer (CRC), breast cancer (BC), and prostate cancer (PCA) in the Japanese population. We also identified pathogenic variants in other cancer risk ge...
 
April 9, 2020
fMRI visualization of learning-related hyper neural activity in Alzheimer’s disease mice 2020:03:04:9:00:41
AbstractAlzheimer’s disease (AD), a neurodegenerative disease, causes behavioural abnormalities such as disinhibition, impulsivity, and hyperphagia. Preclinical studies using AD model mice have investigated these phenotypes by measuring brain activity in awake, behaving mice. In ...
 
March 4, 2020
GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits 2020:02:03:14:35:20
AbstractDietary habits are important factors in our lifestyle, and confer both susceptibility to and protection from a variety of human diseases. We performed genome-wide association studies for 13 dietary habits including consumption of alcohol (ever versus never drinkers and dr...
 
February 3, 2020
Double-parabolic-reflectors acoustic waveguides for high-power medical ultrasound 2019:12:09:10:29:16
AbstractHigh intensity focused ultrasound therapeutics are widely used to noninvasively treat various types of primary tumors and metastasis. However, ultrasound penetration depth is shallowed with increasing frequency which limits the therapeutic accuracy for deep tissues. Altho...
 
December 9, 2019
Characterizing rare and low-frequency height-associated variants in the Japanese population 2019:10:02:14:16:25
AbstractHuman height is a representative phenotype to elucidate genetic architecture. However, the majority of large studies have been performed in European population. To investigate the rare and low-frequency variants associated with height, we construct a reference panel (N = ...
 
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September 16, 2016
Mysterious increased transition temperature of iron selenide superconductor under high pressure 2016:08:02:15:17:33
Hidden relationship between magnetism and superconductivity unveiledResearchers at the University of Tokyo have shown that the mysterious fourfold increase observed in the superconducting transition temperature, or the temperature at which superconductivity emerges, of iron selen...
 
August 2, 2016
Discovery may point to new source of superconductivity 2016:07:15:11:15:03
Non-magnetic electronic state and its singularity discovered in iron-based superconductorsA research team, including members from the University of Tokyo, systematically substituted one atom for another in an iron-based superconductor and discovered a new critical point (singular...
 
July 15, 2016
June 7, 2016
May 16, 2016
Commencement of First-in-Human Clinical Trial for New Molecular Targeting Drug 2016:04:07:22:22:57
TOKYO, Japan (March 22, 2016) –The National Cancer Center, The University of Tokyo, and Daiichi Sankyo Company, Limited (hereafter, Daiichi Sankyo) today announced a collaboration to develop a histone methylation enzyme EZH1/2 dual inhibitor (DS-3201), as a new molecular targeting agent for hematologic malignancy, and the commencement of Phase 1 clinical trial in patients with malignant lymphoma and adult T-cell leukemia-lymphoma (ATL).
 
April 7, 2016
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Discovery of nanoscale dynamics in supersaturation ion networks 2015:12:28:11:27:24
A joint University of Tokyo and Osaka University group used diffracted X-ray tracking to demonstrate that a supersaturated solution, a precursor state to crystal formation, contains local ion networks that show both exited Brownian Motion and extremely small force fields on the femto-Newton scale.
 
December 28, 2015
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Visualizing RNAi at work 2015:07:03:9:27:23
University of Tokyo and Kyoto University researchers have revealed the molecular mechanism of RNA interference (RNAi), the phenomenon by which the synthesis of a specific protein is inhibited, by real time observation of target RNA cleavage at the single-molecule level.
 
July 3, 2015
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Visualizing the bonding properties of liquid boron 2015:05:01:18:03:54
Boron (B) belongs to the group of element situated between metals and insulators in the periodic table. Though the balance between metallic and insulating tendencies could be altered via pressure and temperatures, the question of whether liquid B is metal or not remains controversial and unsolved. We have carried out high resolution Compton scattering measurements on solid and liquid B and interpreted the results in terms of CPMD simulations, and then conclude that semiconducting properties dominates the physical properties of liquid B.
 
May 1, 2015
Riddle of mimicry of unpalatable butterfly 2015:04:14:9:31:47
Molecular mechanism of Batesian mimicry in Papilio polytesUniversity of Tokyo researchers have revealed the whole genome sequences of two swallowtail butterflies Papilio polytes, the females of which mimic the unpalatable butterfly Pachliopta aristolochiae, and Papilio xuthus, wh...
 
April 14, 2015
Antigen complex single molecule observation with X-rays 2015:02:06:16:59:38
A research group led by Professor Yuji C. Sasaki at the Graduate School of Frontier Sciences, the University of Tokyo, and Associate Professor Haruo Kozono at the Research Institute for Biomedical Sciences, Tokyo University of Science, successfully observed the three-dimensional (3D) dynamic single-molecule internal motions of a peptide bound to major histocompatibility complex (MHC) for the first time. MHC is an important protein that controls acquired immune response, presenting pathogens that invade the body to immune cells. The group used the SPring-8 BL40XU beamline to discover how MHC binds to pathogen proteins (antigen peptides) and activates the immune system by observing the internal dynamics of single molecules.
 
February 6, 2015

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